Suppressive CpG

Suppressive CpG

Cellular constipation can be deadly, according to a study on page 1587. Wang and colleagues show that cells get clogged with aborted secretory cargo when they lack an enzyme that helps form vesicles. Deletion of this enzyme proved lethal in mice, halting brain, bone and vascular development. The enzyme in question is a protein tyrosine phosphatase (PTP) called MEG2. MEG2 binds lipids and reside...

Immune Activation Effect of Suppressive DNA on CpG-Induced

Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas.

PURPOSE IDH1/2-mutant gliomas harbor a distinct glioma-CpG island methylation phenotype (G-CIMP) that may promote the initiation and progression of secondary pathway gliomas by silencing tumor-suppressive genes. The potential role of tumor-suppressive microRNAs (miRNA; miR) in this process is not understood. EXPERIMENTAL DESIGN To identify potential tumor-suppressive miRNA hypermethylated in ...

CpG and Non-CpG Oligodeoxynucleotides

Presence of CpG DNA and the local cytokine milieu determine the efficacy of suppressive DNA vaccination in experimental autoimmune encephalomyelitis.

We here study the adjuvant properties of immunostimulatory DNA sequences (ISS) and coinjected cytokine-coding cDNA in suppressive vaccination with DNA encoding an autoantigenic peptide, myelin basic protein peptide 68-85, against Lewis rat experimental autoimmune encephalomyelitis (EAE). EAE is an autoaggressive, T1-mediated disease of the CNS. ISS are unmethylated CpG motifs found in bacterial...